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Previous studies have reported that anal cancer incidence has increased in individual countries; however, age-specific trends were not examined in detail. The standardised rate ratios SRRs for — vs — and the 5-year average percent change AvPC during the period were used to assess changes in the age-standardised incidence rates. These competing trends still resulted in significant increases in the overall incidence of anal cancer in men and women of all ages groups with significant increasing trend. The corresponding SRRs in women were 1. Increases in the incidence of anal SCC has driven an overall increase in anal cancer incidence; this may be associated with changing sexual behaviours and increasing levels of HPV exposure in younger cohorts. The findings further reinforce the importance of HPV vaccination.
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