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Arginine deiminase ADI , an arginine-degrading enzyme, has been used in the treatment of tumours sensitive to arginine deprivation, such as malignant melanoma MM and hepatocellular carcinoma HCC. Endogenous production of arginine is mainly dependent on activity of ornithine transcarbamylase OTC and argininosuccinate synthetase ASS enzymes. Twenty-five primary melanoma cell lines and normal fibroblasts as controls underwent cell proliferation assays and Western blot analyses in the presence or absence of ADI. Lack of ASS immunostaining was observed in all analyzed in vivo specimens. Our findings suggest that response to ADI treatment in melanoma is significantly correlated with the ability of cells to express ASS either constitutively at basal level inducing drug resistance or after the treatment reducing sensitivity to ADI. Abstract Arginine deiminase ADI , an arginine-degrading enzyme, has been used in the treatment of tumours sensitive to arginine deprivation, such as malignant melanoma MM and hepatocellular carcinoma HCC.
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Clip art illustrating short thank you. Only credit in issue is on this page " Dumb-Ass Express 1. Published in English United States.
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Picking up a semi-autobiographical account of the adventures of an Indian lawyer does not seem to be the best way to spend a holiday. What sets it apart from the plethora of books on the legal profession is that it tells us how the legal profession actually functions — does it actually? In doing so, it also exposes, with humour, all that is wrong with the system. It is a John Grisham legal thriller in an Indian setting.
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